Инд. авторы:	Purtov K.V., Puzyr A.P., Bondar V.S., Petunin A.I., Burov A.E.
Заглавие:	Nanodiamonds as carriers for address delivery of biologically active substances
Библ. ссылка:	Purtov K.V., Puzyr A.P., Bondar V.S., Petunin A.I., Burov A.E. Nanodiamonds as carriers for address delivery of biologically active substances // Nanoscale Research Letters. - 2010. - Vol.5. - Iss. 3. - P.631-636. - ISSN 1931-7573. - EISSN 1556-276X.
Внешние системы:	DOI: 10.1007/s11671-010-9526-0; РИНЦ: 15324308; WoS: 000276180500031;
Реферат:	eng: Surface of detonation nanodiamonds was functionalized for the covalent attachment of immunoglobulin, and simultaneously bovine serum albumin and Rabbit Anti-Mouse Antibody. The nanodiamond-IgG(I125) and RAM-nanodiamond-BSA(I125) complexes are stable in blood serum and the immobilized proteins retain their biological activity. It was shown that the RAM-nanodiamond-BSA(I125) complex is able to bind to the target antigen immobilized on the Sepharose 6B matrix through antibody-antigen interaction. The idea can be extended to use nanodiamonds as carriers for delivery of bioactive substances (i.e., drugs) to various targets in vivo.
Ключевые слова:	Nanodiamonds; Ligand; Protein immobilization; Nanocarrier; Targeted delivery; ANTICANCER DRUGS; NANOPARTICLES; ADSORPTION; PARTICLES; PROTEINS;
Издано:	2010
Физ. характеристика:	с.631-636